Impact of Steviol Glycosides, Moderate Intensity Swimming, and Intermittent Fasting on the Profile of Fasting Blood Glucose Levels, Malondialdehyde, and Lipidemia in Dmt2-Induced Rats

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by impaired glucose regulation, lipid abnormalities, and increased oxidative stress. This study aimed to evaluate the effects of steviol glycosides, moderate-intensity swimming, and intermittent fasting on fasting blood glucose, malondialdehyde (MDA), and lipid profiles in a rat model of T2DM. A laboratory-based quasi-experimental study with a pretest–posttest group design was conducted using 30 male Wistar rats allocated to five groups: untreated control, metformin, steviol glycosides, moderate-intensity swimming, and intermittent fasting. Each group received its assigned intervention during the study period. Fasting blood glucose levels were monitored on days 4, 7, 10, 13, 16, and 19, while MDA and lipid profiles were assessed as indicators of oxidative stress and lipid metabolism, respectively. The data were analyzed using the Wilcoxon test. The reported statistical analysis indicated significant differences at the specified measurement time points; however, the available results did not provide sufficient information to establish the magnitude of the changes or determine which intervention produced the most favorable outcomes. Therefore, the findings should be interpreted cautiously until the group-specific results and corresponding statistical values are reported. This study provides a framework for investigating the potential metabolic effects of steviol glycosides, moderate-intensity swimming, and intermittent fasting in experimental T2DM. Further studies should report quantitative changes in glucose, MDA, and lipid parameters, clarify the effects of each intervention, and evaluate the reproducibility of the findings before concluding their therapeutic potential.