Serum Resistin in Iraqi Men with Prostate Cancer: Associations with Renal Function and Serum Electrolytes

Abstract

Background: Resistin is an inflammatory adipokine produced mainly by monocytes and macrophages in humans. Evidence linking circulating resistin to prostate cancer is limited and inconsistent.
Objective: To compare serum resistin between men with prostate cancer and controls and to examine its association with creatinine, urea, sodium, and potassium.
Methods: A case-control study was conducted in men with prostate cancer and apparently healthy controls. Serum resistin and the selected biochemical variables were measured, group values were compared, and correlations with resistin were calculated.
Results: The reported resistin value was 34.01 ng/mL in the prostate cancer group, compared with a control interval of 7-22 ng/mL (p <= 0.01). Creatinine and urea were higher in patients, whereas sodium and potassium were lower. Resistin correlated positively with creatinine (r = 0.401), urea (r = 0.322), potassium (r = 0.207), and sodium (r = 0.158).
Conclusion: Higher resistin accompanied renal and electrolyte abnormalities in the patient group. Renal impairment may had been influence circulating resistin; therefore, these current findings should be interpreted as an associations rather than evidence of diagnostic or prognostic utility. Confirmation requires a larger, clinically characterized cohort and multivariable analysis.