Variation in Two Behavior Hormones Concentration in Patients with Clinical Amoebiasis and their Impact on Activity of Digestive Related Enzymes

Abstract

Entamoebiasis infection is a globally and locally distributed intestinal protozoan parasite, which is able to harm lower GIT, and may disseminate out of intestine. The aim of the present study was to investigate the possible role of serious amoebiasis infection on cortisol and oxytocin hormones in clinically infected patients and tracing the change in the activity of four enzymes those associated with digestion and processing of nutrients. 169 participants were subjected to the present study; their ages were ranged between18-50 years old. The sampling includes three groups; control group (60 participants) those have no common chronic diseases, the other 109 participant were patients with chronic GIT disturbance, who revised endoscopy unites in Ibn Sina Teaching Hospital and Medical Research Educational Hospital in Nineveh Governorate, Who had GIT disturbance. 60 patients of the 109 proved microscopically to have intestinal amoebiasis. Sampling was performed during the period from September 2025 to February 2026. Blood and Stool sample were collected from the participant added to inspired materials in case of endoscopy. Concentrations of cortisol and oxytocin hormones were estimated in blood. Furthermore, activity of the digestive enzymes; pancreatic amylase and lipase added to the liver enzymes; ALT and FASN were estimated also. Total blood protein, fasting blood glucose and triglycerides concentrations were estimated also. Significant increment at P≤0.05were recorded in concentration of blood cortisol and decrement in concentration of blood Oxytocin were recorded in Clinical amoebiasis cases. Significant Increment in activities of Pancreatic lipase and amylase were recorded also.