A Randomized Controlled Trial of Intradermal Injection Autologous Platelet-Rich Plasma Versus Platelet-Rich Fibrin in the Treatment of Melasma and Striae Distensae

Abstract

Melasma and striae distensae (SD) are two prevalent dermatological disorders that affect more women, particularly those with darker skin. Traditional treatments can produce variable results with potential negative effects. This randomized, split-face and split-abdomen controlled trial involved twenty participants and compared the efficacy of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in treating melasma and SD. At baseline, week 4, and week 8, everyone received intradermal injections of PRP on one side of the face and belly, and PRF on the opposite side. Outcome assessments included the Mexameter® for melanin and erythema indices, the Modified Melasma Area and Severity Index (mMASI), Antera 3D® imaging, patient satisfaction scores, and the Patient and Observer Scar Assessment Scale (POSAS). PRF significantly reduced pigmentation and melanin index, leading to increased patient satisfaction by week 12 (p < 0.05). The Antera 3D® data also revealed that PRF-treated striae performed better in terms of redness and texture. There were no major negative effects noted. These data indicate that PRF may provide more clinical advantages than PRP for pigmentation problems and atrophic scarring.