Hippocampal BDNF Expression From Early Development to Adulthood in Male Rats

Abstract

The hippocampus plays a crucial role in our memory. The manner in which we experience emotions and acquire knowledge. This research examined a substance known as BDNF, a specific type of stain, and its influence on the growth of the hippocampus in male albino rats at various ages. They divided twenty albino rats into four groups: one group was only one day old, another group was one month old, a third group was three months old, and the final group consisted of adult rats. Every one of these groups contained five rats. The BDNF expression in the CA1 region varied with age. At 1 day,  observed minimal BDNF. At one month, there was an increased expression of  BDNF. After 3 months, the BDNF decreased slightly. At 6 months, the CA1 area exhibited increased BDNF, notably in the stratum pyramidal. The CA3 subfield exhibited differences. At 1 day and 1 month, did not observe BDNF. At 3 months, the BDNF increased expression in the stratum oriens. At 6 months, there were increased neurons containing BDNF in the stratum oriens and stratum radiatum of the CA3 subfield. The dentate gyrus exhibited marked age-related variations, showing no observable staining at 1day, restricted expression in the polymorphic layer at 1 month, a slight rise at 3 months, and many BDNF-positive neurons at 6 months. The study shows the increase of BDNF expression related with age.